O2-Assisted Four-Component Reaction of Vinyl Magnesium Bromide with Chiral N-tert-Butanesulfinyl Imines To Form syn-1,3-Amino Alcohols was written by Wang, Runping;Luo, Jingfan;Zheng, Chunmei;Zhang, Hongyun;Gao, Lu;Song, Zhenlei. And the article was included in Angewandte Chemie, International Edition in 2021.Name: 1-Boc-Azetidine-3-yl-methanol This article mentions the following:
An O2-assisted, four-component reaction has been developed to synthesize a wide range of syn-1,3-amino alcs. in one step. The reaction proceeds by oxygenation of vinyl magnesium bromide (component-I) with O2 (component-II) to give a magnesium enolate of acetaldehyde, which undergoes addition to a chiral N-tert-butanesulfinyl imine (component-III) followed by a sequential addition with excess vinyl magnesium bromide (component-IV). The approach allows diastereoselective synthesis of anti/syn- and syn/syn-3-amino-1,5-diols in good yields with high diastereoselectivity. The method was illustrated in an efficient, four-step synthesis of piperidine alkaloid (-)-2′-epi-ethylnorlobelol. In the experiment, the researchers used many compounds, for example, 1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3Name: 1-Boc-Azetidine-3-yl-methanol).
1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Name: 1-Boc-Azetidine-3-yl-methanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts