Amino Alcohols and Derivatives with Therapeutic Properties. II was written by Fourneau, E.. And the article was included in Journal de Pharmacie et de Chimie in 1911.Product Details of 14123-48-9 This article mentions the following:
Dimethylaminodimethylethylcarbinol, Me2NCH2CMeEtOH, (1) by heating C6H6 solution of Me2NH with ClCH2MeCEtOH in a sealed tube, or (2) from Me2NH and EtMeC – CH2 in the same way, or (3) by the action of EtMgBr on Me2NCH2Ac; colorless liquid b. 149°, methiodide, prisms, m. 126°. The other bases described were prepared similarly. Diethylaminodimethylethylcarbinol. Dimethylaminotrimethylcarbinol, b758 130°. Methiodide, prisms, m. 130°. Dimethylaminodimethylpropylcarbinol, b25 78°. Methiodide, plates, m. 151°. Dimethylaminodimethylisoamylcarbinol, b758 199.5°. Hydrochloride, leaflets, m. 145°. Dimethylaminodimethylphenylcarbinol. Dimethylaminodimethylbenzylcarbinol, b241 144°. Dimethylaminodiethylmethylcarbinol, from EtMgBr and Me2NCH2CO2Et, or EtMgBr and ClCH2CO2Et, followed by Me2NH, b. 170°. Methiodide, prisms, m. 134°. Starting with excess of NH3, by method (1) both primary and secondary bases are obtained. Aminodimethylethylcarbinol, H2NCH2CMeEtOH, syrup with nicotine odor, b. 170°, not precipitated by the usual alkaloid reagents. Hydrochloride, hygroscopi leaflets, m. 90°. Aminobisdimethylethylcarbinol, syrup with strong odor, b26 165-6°. Hydrochloride, brilliant, non-hygroscopic leaflets. Aminodimethylisoamylcarbinol, b60 125°. Aminobisdimethylisoamylcarbinol, crystalline, b45 206°. Hydrochloride, difficultly soluble in H2O, affording a separation from the primary base, m. 183°. Aminodimethylphenylcarbinol, b40 174-5°. Aminobisdimethylphenylcarbinol, b40 258°. Hydrochloride, slightly soluble in H2O, leaflets, m. 228-9°. Methylaminodimethylethylcarbinol, b. 160°. In the experiment, the researchers used many compounds, for example, 1-(Dimethylamino)-2-methylpropan-2-ol (cas: 14123-48-9Product Details of 14123-48-9).
1-(Dimethylamino)-2-methylpropan-2-ol (cas: 14123-48-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Product Details of 14123-48-9
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts