Recommendation to include hydroxyethyl (meth)acrylate in the British baseline patch test series was written by Rolls, S.;Chowdhury, M. M.;Cooper, S.;Cousen, P.;Flynn, A. M.;Ghaffar, S. A.;Green, C. M.;Haworth, A.;Holden, C.;Johnston, G. A.;Naidoo, K.;Orton, D. I.;Reckling, C.;Sabroe, R. A.;Scorer, M.;Stone, N. M.;Thompson, D.;Wakelin, S.;Wilkinson, M.;Buckley, D. A.. And the article was included in British Journal of Dermatology in 2019.Synthetic Route of C16H26O7 This article mentions the following:
(Meth)acrylates are potent sensitizers and a common cause of allergic contact dermatitis (ACD). The frequency of (meth)acrylate ACD has increased with soaring demand for acrylic nails. A preliminary audit has suggested a significant rate of pos. patch tests to (meth)acrylates using aimed testing in patients providing a clear history of exposure. To determine whether inclusion of 2-hydroxyethyl methacrylate (2-HEMA) 2% in petrolatum (pet.) in the baseline series detects cases of treatable (meth)acrylate ACD. During 2016-2017, 15 U.K. dermatol. centers included 2-HEMA in the extended baseline patch test series. Patients with a history of (meth)acrylate exposure, or who tested pos. to 2-HEMA, were selectively tested with a short series of eight (meth)acrylate allergens. In total 5920 patients were consecutively patch tested with the baseline series, of whom 669 were also tested with the (meth)acrylate series. Overall, 102 of 5920 tested pos. to 2-HEMA and 140 to at least one (meth)acrylate. Had 2-HEMA been excluded from the baseline series, (meth)acrylate allergy would have been missed in 36 of 5920. The top (meth)acrylates eliciting a pos. reaction were 2-HEMA, 2-hydroxypropyl methacrylate and 2-hydroxyethyl acrylate. 2-HEMA 2% pet. be added to the British baseline patch test series. We also suggest a standardized short (meth)acrylate series, which is likely to detect most cases of (meth)acrylate allergy. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Synthetic Route of C16H26O7).
((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Synthetic Route of C16H26O7
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts