Highly efficient asymmetric hydrogenation of alkyl aryl ketones catalyzed by iridium complexes with chiral planar ferrocenyl phosphino-thioether ligands was written by Le Roux, Erwan;Malacea, Raluca;Manoury, Eric;Poli, Rinaldo;Gonsalvi, Luca;Peruzzini, Maurizio. And the article was included in Advanced Synthesis & Catalysis in 2007.Application In Synthesis of (S)-1-(2-Fluorophenyl)ethanol This article mentions the following:
Ir complexes of planar-chiral ferrocenyl phosphine-thioether ligands were tested in the hydrogenation of simple ketones. Optimization of the conditions led to a highly active catalytic system with turnover numbers up to 915 and turnover frequencies up to ∼250 h-1. Also, very high enantioselectivities (up to > 99%) together with complete conversions were obtained for the asym. hydrogenation of various acetophenones at 10°. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Application In Synthesis of (S)-1-(2-Fluorophenyl)ethanol).
(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application In Synthesis of (S)-1-(2-Fluorophenyl)ethanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts