Identification of chemicals leaching from dental resin-based materials after in vitro chemical and salivary degradation was written by Vervliet, Philippe;De Nys, Siemon;Duca, Radu Corneliu;Boonen, Imke;Godderis, Lode;Elskens, Marc;Van Landuyt, Kirsten L.;Covaci, Adrian. And the article was included in Dental Materials in 2022.Application In Synthesis of 2,2′-Oxybis(ethan-1-ol) This article mentions the following:
Only little is known about degradation of methacrylate monomers. Therefore, using in vitro chem. and saliva degradation this study aimed to identify the degradation products of organic compounds present in resin-based dental materials. Ten dental monomers and nine polymerized dental resin-based materials were immersed for 24 h in chem. media (0.1 M HCl, 0.1 M NaOH) and human pooled saliva in order to identify leached monomers and degradation products from chem. and saliva degradation Samples were analyzed using liquid chromatog. coupled to high-resolution mass spectrometry to identify previously unknown degradation products. During in vitro chem. degradation, uncured monomers were rapidly hydrolyzed into mono- and demethacrylated degradation products. During chem. degradation in alk. conditions of polymerized materials, considered the worst-case scenario, only degradation products could be detected. In acidic conditions, monomers and their degradation products were detected. In addition, different additives such as EDMAB, DMPA and HMBP were present in acidic degradation samples. Degradation in human pooled saliva for 24 h to mimic the in vivo situation, resulted in the identification of both monomers and their degradation products. Using state-of-the-art high-resolution mass spectrometry previously unknown degradation products of commonly used monomers were identified for the first time. Patients may be exposed to monomers and their degradation products in the first 24 h after restorative procedures. The results provide a base for further research on the degradation of resin-based dental composites in order to assess their safety using elution and toxicity studies. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Application In Synthesis of 2,2′-Oxybis(ethan-1-ol)).
2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application In Synthesis of 2,2′-Oxybis(ethan-1-ol)
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts