Expert opinion on existing and developing drugs to treat female sexual dysfunction was written by Miller, Melanie K.;Smith, Joshua R.;Norman, Jacqueline J.;Clayton, Anita H.. And the article was included in Expert Opinion on Emerging Drugs in 2018.Formula: C24H23ClO2 This article mentions the following:
Female sexual dysfunction (FSD) is a highly prevalent, yet commonly underdiagnosed and undertreated condition. This paper reviews the diagnostic terminol. for FSD, and basic sexual physiol. in women. The Food and Drug Administration (FDA) approved drugs for FSD are discussed, followed by investigational drugs for FSD currently in phase 2 or 3 clin. trials, reasons for failure of drug development, and potential future drug targets. A literature review was conducted for available treatments for FSD: flibanserin, estrogen, ospemifene and prasterone. Potential treatments are assessed, as was the Pharmaprojects database which includes clin. trial information. Testosterone, bremelanotide, bupropion-trazodone, PDE-5 inhibitors, prostaglandins, tibolone and combination therapies, and the theor. basis of potential drug targets are discussed. The lack of established endpoints for phase 3 studies of FSD has impeded approval of new treatments, and required addnl. studies for validation, resulting in proposed changes to the FDA draft guidance for FSD clin. trials in Oct. 2016. Current DSM-5 diagnostic nosol. also fails to capture the full range of symptomol. Several promising compounds have shown no movement for several years limiting women’s options. Overcoming socio-cultural bias against women’s sexual and reproductive health will be critical in the approval of new treatments for FSD. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Formula: C24H23ClO2).
(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Formula: C24H23ClO2
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts