Enantioselective C-H bond functionalization of aromatic ketones with 1,6-enynes via photoredox/cobalt dual catalysis was written by Maji, Kakoli;Thorve, Pradip Ramdas;Rai, Pramod;Maji, Biplab. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Formula: C10H20O This article mentions the following:
An enantioselective ortho-C(sp2)-H functionalization of ketones/esters, e.g., I (R1 = Me, Et, Ph, OMe; R2 = H, 4-F, 3-MeO, 3,4-benzo, etc.) with 1,6-enynes II [Ar = Ph, X = NTs, O, C(COOMe)2; Ar = 3-ClC6H4, 4-MeOC6H4, 3,5-Me2C6H3, etc., X = NTs] is demonstrated via photoredox/cobalt dual catalysis. The method provides the corresponding arylmethylene-substituted carbo- and heterocycles III in high yields with functional group tolerance and selectivity. Mechanistic studies suggested the operation of visible-light mediated low-valent cobalt complex generation, intramol. cyclization, ortho-C-H bond insertion, and reductive elimination as the key mechanistic steps. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Formula: C10H20O).
(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C10H20O
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts