Asymmetric Reduction of Ketones by the Acetone Powder of Geotrichum candidum was written by Nakamura, K.;Matsuda, T.. And the article was included in Journal of Organic Chemistry in 1998.Safety of (S)-1-(2-Fluorophenyl)ethanol This article mentions the following:
Aromatic ketones, β-keto esters, and simple aliphatic ketones were reduced with excellent selectivity to the corresponding (S)-alcs. by using the acetone powder of Geotrichum candidum. This method is superior in reactivity and stereoselectivity to reduction by the whole-cell. The exptl. conditions for the reduction system such as ratio of the biocatalyst to the substrate, kinds of coenzymes, alc. for coenzyme regeneration, and buffer, pH, and reaction temperature were investigated, and stability and preservability of the biocatalyst were also examined This method is very convenient for the synthesis of optically pure alcs. on a gram scale. E.g., 2-chloroacetophenone was reduced to (S)-2-ClC6H4CH(OH)Me in >99% ee and 94% isolated yield by reduction with the acetone powder of Geotrichum candidum as the catalyst, NAD+ as a coenzyme, and Me2CHOH as the reducing agent in MES [2-(N-morpholine)ethanesulfonic acid-NaOH] buffer. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Safety of (S)-1-(2-Fluorophenyl)ethanol).
(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Safety of (S)-1-(2-Fluorophenyl)ethanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts