Radical cascade synthesis of azoles via tandem hydrogen atom transfer was written by Chen, Andrew D.;Herbort, James H.;Wappes, Ethan A.;Nakafuku, Kohki M.;Mustafa, Darsheed N.;Nagib, David A.. And the article was included in Chemical Science.Application of 2968-93-6 This article mentions the following:
A radical cascade strategy for the modular synthesis of five-membered heteroarenes (e.g. oxazoles, imidazoles) I (R1 = Ph, 4-MeOC6H4, 4-F3C6H4, 2-naphthyl, biphenyl-4-yl, etc.; R2 = Ph, 2-pyridinyl, 4-IC6H4, 3-MeC6H4, etc.), II (R3 = 4-F3CC6H4, CCl3) from feedstock reagents (e.g. alcs., (R2CH2CH2OH), amines (such as., benzylamine, morpholine, pyrrolidine), nitriles R1CN) has been developed. This double C-H oxidation is enabled by in situ generated imidate R1C(=N)OCH2CH2R2 and acyloxy radicals, which afford regio- and chemo-selective β C-H bis-functionalization. The broad synthetic utility of this tandem hydrogen atom transfer (HAT) approach to access azoles is included, along with experiments and computations that provide insight into the selectivity and mechanism of both HAT events. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Application of 2968-93-6).
2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application of 2968-93-6
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts