Enantioselective synthesis of diisopropyl α-, β-, and γ-hydroxyarylalkylphosphonates from ketophosphonates: a study on the effect of the phosphonyl group was written by Meier, Chris;Laux, Wolfgang H. G.. And the article was included in Tetrahedron in 1996.Electric Literature of C8H9FO This article mentions the following:
A comparative study of different reduction conditions to an enantioselective synthesis of diisorpropyl α-, β- and γ-hydroxyphosphonates by 1,3,2-oxaborolidine catalysis using catecholborane or BH3·Me2S is described. The comparison to acetophenone reductions gave information’s on the effect of the phosphonyl group during the reduction of ketophosphonate. So very efficient syntheses to chiral dialkyl α-, β- and γ-hydroxyphosphonates were elaborated. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Electric Literature of C8H9FO).
(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Electric Literature of C8H9FO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts