Discovery and Characterization of 2-Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 Agonists was written by Galley, Guido;Beurier, Angelica;Decoret, Guillaume;Goergler, Annick;Hutter, Roman;Mohr, Susanne;Pahler, Axel;Schmid, Philipp;Turck, Dietrich;Unger, Robert;Zbinden, Katrin Groebke;Hoener, Marius C.;Norcross, Roger D.. And the article was included in ACS Medicinal Chemistry Letters in 2016.Related Products of 926291-77-2 This article mentions the following:
2-Aminooxazolines were discovered as a novel structural class of TAAR1 ligands. Starting from a known adrenergic compound, structural modifications were made to obtain highly potent and selective TAAR1 ligands such as (I) (RO5166017), (II) (RO5256390), RO5203648, and RO5263397. These compounds exhibit drug-like physicochem. properties, have good oral bioavailability, and display in vivo activity in a variety of animal models relevant for psychiatric diseases and addiction. In the experiment, the researchers used many compounds, for example, (R)-2-Amino-2-(3-chlorophenyl)ethanol (cas: 926291-77-2Related Products of 926291-77-2).
(R)-2-Amino-2-(3-chlorophenyl)ethanol (cas: 926291-77-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Related Products of 926291-77-2
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts