Dependence of the antimicrobial activity of chemical preservatives in suspensions on several pharmaceutical factors was written by Pertsev, I. M.;Khokhlova, L. N.;Dmitrievskii, D. I.. And the article was included in Khimiko-Farmatsevticheskii Zhurnal in 1984.Name: rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate This article mentions the following:
The adsorption of chem. preservatives such as nipagin [99-76-3], nipazol [94-13-3], sorbic acid [110-44-1], benzoic acid [65-85-0], benzalkonium chlorides and ethonium [21954-74-5] by solid phase drug-suspensions was studied. The suspensions contained Al2O3, BaSO4, Ca glycerophosphate [27214-00-2], MgCO3, MgO, menthol [1490-04-6], talc, terpin hydrate [2451-01-6], phenyl salicylate [118-55-8] and phthalazole [85-73-4] in 1, 2.5 and 5% concentrations The quantity of the adsorbed preservatives increased with the concentration of solid phases up to 2.5% drug concentration Since nipagin and nipazole showed the least adsorption, a combination of these was chosen for preserving the suspensions and their concentration increased to study their adsorption. Since benzoic acid and sorbic acid adsorbed most of the drugs used they should not be used as preservatives. In addition, the effect of stabilizers, Tween 80 [9005-65-6] Me cellulose [9004-67-5], and gelatose [52624-15-4] on the adsorption of the preservatives were studied. Tween 80 increased the adsorption degree of all the preservatives studied, gelatose decreased it and Me cellulose also increased the degree of adsorption of all the preservatives except that of sorbic acid. The antimicrobial activity was decreased when the stabilizers were not used, especially with sorbic acid. The stabilizers in general increased the antimicrobial activity. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Name: rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate).
rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Name: rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate
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