A novel approach for the preparation of core-shell MOF/polymer composites as mixed-mode stationary phase was written by Si, Tiantian;Wang, Licheng;Zhang, Haixia;Liang, Xiaojing;Lu, Xiaofeng;Wang, Shuai;Guo, Yong. And the article was included in Talanta in 2021.Name: (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate This article mentions the following:
The nickel organic framework capped with polyvinylpyrrolidone was prepared and synergistically immobilized onto porous silica surface as the mixed-mode stationary phase for high-performance liquid chromatog. Here, polyvinylpyrrolidone firstly was chosen as functional mols. to change morphol. and size of the metal organic framework. The silica microspheres were then modified by them via a simple bonding method rather than in-situ growth method with the aid of electrostatic interaction commonly used before. The stationary phase showed flexible selectivity for separation of both hydrophilic and hydrophobic compounds, especially for hydrophilic compounds such as carbohydrates, alkaloids and sulfonamides etc. The chromatog. behaviors were evaluated by investigating various factors, and a typical mixed-mode retention feature of the column was observed The composites could be prepared repetitively, and relative standard deviations of retention time of objective compounds among different batches were less than 1.75%. It also showed excellent chromatog. reproducibility, stability and potentiality for application in real samples. In short, the composites can be used for a feasible option for anal. of multiple compounds as the mixed-mode stationary phase and it provides a general approach for preparing MOFs-based composites by changing morphol. and size of MOFs. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Name: (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate).
(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Name: (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts