Organocatalytic Chlorination of Alcohols by P(III)/P(V) Redox Cycling was written by Longwitz, Lars;Jopp, Stefan;Werner, Thomas. And the article was included in Journal of Organic Chemistry in 2019.Recommanded Product: 2-(Trifluoromethyl)phenethyl alcohol This article mentions the following:
A catalytic system for the chlorination of alcs. under Appel conditions was developed. Benzotrichloride was used as a cheap and readily available chlorinating agent in combination with trioctylphosphine as the catalyst and phenylsilane as the terminal reductant. The reaction has several advantages over other variants of the Appel reaction, e.g., no addnl. solvent is required and the phosphine reagent was used only in catalytic amounts In total, 27 different primary, secondary, and tertiary alkyl chlorides were synthesized in yields up to 95%. Under optimized conditions, it was also possible to convert epoxides and an oxetane to the dichlorinated products. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Recommanded Product: 2-(Trifluoromethyl)phenethyl alcohol).
2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: 2-(Trifluoromethyl)phenethyl alcohol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts