Cu(II), Ni(II) complexes derived from chiral Schiff-base ligands: Synthesis, characterization, cytotoxicity, protein and DNA-binding properties was written by Li, Zhen;Yan, Hui;Chang, Guoliang;Hong, Min;Dou, Jianmin;Niu, Meiju. And the article was included in Journal of Photochemistry and Photobiology, B: Biology in 2016.Recommanded Product: (R)-2-Aminobutan-1-ol This article mentions the following:
A series of novel copper(II) and nickel(II) complexes derived from chiral Schiff-base ligands [(R)/(S)-H2L1 = (R)/(S)-2-[(1-Hydroxymethyl-propylimino)-methyl]-5-methoxy-phenol and (R)/(S)-H2L2 = (R)/(S)-2-[(1-Hydroxymethyl-2-phenyl-ethylimino)-methyl]-5-methoxy-phenol], were synthesized and characterized by elemental analyses, 1H NMR spectra, FTIR spectrum. The crystal structures of 1–5 [Ni2L2(OAc)2(solv)2] were determined through single crystal x-ray diffraction (SXRD). The structures showed the ligands coordinated to the Cu/Ni(II) ion in a neutral manner via ONO donor atoms, and oxygen atoms of solvent mols. occupy the axial positions in Ni(II) complexes 3 and 4. The complexes interactions with BSA and CT-DNA were investigated by various spectroscopic methods (UV-Visible, CD spectrum, fluorescence spectroscopic and synchronous fluorescence spectra). Interactions of chiral copper(II) complexes are stronger than nickel(II) complexes. Further, the cytotoxicities of 1–6 towards three kinds of cancerous cell lines, were human lung adenocarcinoma (A549), human cervical carcinoma cell (HeLa) and human breast cancer cell (MCF-7), resp., were evaluated by MTT assay. All complexes exhibited good cytotoxic activity. Furthermore, Cu(II) complex 5 derived from (R)-Schiff-base ligand is more effective towards HeLa cancerous cell. Chirality and metal ion have important influence on their anticancer activities and interactions with DNA/BSA. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Recommanded Product: (R)-2-Aminobutan-1-ol).
(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: (R)-2-Aminobutan-1-ol
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