Evidence for distinct mechanisms of small molecule inhibitors of filovirus entry was written by Schafer, Adam;Xiong, Rui;Cooper, Laura;Nowar, Raghad;Lee, Hyun;Li, Yangfeng;Ramirez, Benjamin E.;Peet, Norton P.;Caffrey, Michael;Thatcher, Gregory R. J.;Saphire, Erica Ollmann;Cheng, Han;Rong, Lijun. And the article was included in PLoS Pathogens in 2021.Synthetic Route of C24H23ClO2 This article mentions the following:
Many small mols. have been identified as entry inhibitors of filoviruses. However, a lack of understanding of the mechanism of action for these mols. limits further their development as anti-filoviral agents. Here we provide evidence that toremifene and other small mol. entry inhibitors have at least three distinctive mechanisms of action and lay the groundwork for future development of anti-filoviral agents. The three mechanisms identified here include: (1) direct binding to the internal fusion loop region of Ebola virus glycoprotein (GP); (2) the HR2 domain is likely the main binding site for Marburg virus GP inhibitors and a secondary binding site for some EBOV GP inhibitors; (3) lysosome trapping of GP inhibitors increases drug exposure in the lysosome and further improves the viral inhibition. Importantly, small mols. targeting different domains on GP are synergistic in inhibiting EBOV entry suggesting these two mechanisms of action are distinct. Our findings provide important mechanistic insights into filovirus entry and rational drug design for future antiviral development. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Synthetic Route of C24H23ClO2).
(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Synthetic Route of C24H23ClO2
Referemce:
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Alcohols – Chemistry LibreTexts