Reactivity-based one-pot synthesis of the tumor-associated antigen N3 minor octasaccharide for the development of a photo-cleavable DIOS-MS sugar array was written by Lee, Jinq-Chyi;Wu, Chung-Yi;Apon, Junefredo V.;Siuzdak, Gary;Wong, Chi-Huey. And the article was included in Angewandte Chemie, International Edition in 2006.Quality Control of 3-(Hydroxymethyl)-4-nitrophenol This article mentions the following:
Readily available thioglycosides with defined relative reactivity values were used as building blocks in a one-pot strategy to synthesize the tumor-associated oligosaccharide antigen N3 minor. The target mol. was attached covalently to a porous silicon surface through a photo-cleavable linker for direct characterization in a mass spectrometer equipped with a laser source. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Quality Control of 3-(Hydroxymethyl)-4-nitrophenol).
3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Quality Control of 3-(Hydroxymethyl)-4-nitrophenol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts