Synthesis of some new sulfonylureas was written by Loev, Bernard;Snader, Kenneth M.;Walz, Donald T.. And the article was included in Journal of Medicinal Chemistry in 1963.SDS of cas: 2968-93-6 This article mentions the following:
The sulfonamides were prepared by treating the sulfonyl chlorides with anhydrous NH3. The styrene sulfonamides were prepared according to Bordwell, et al. (CA 40, 14665, 71761). The sulfonylureas were prepared by treating the sulfonamide with BuNCO in aqueous Me2CO and the amino-substituted sulfonylurea was prepared by treating the isocyanate with the aminosulfonamide and by reduction of the nitrosulfonylurea. The following I were prepared (X, A, and m.p. given): 4-Cl, CH2, 180-1°; 4-NO2, CH2 (II), 193.5-4.5°; H, CH2CH2, 159-61°; 4-NO2, CH2CH2, 153-5°; 2-NO2, CH2CH2, 154-6°; 4-NH2, CH2CH2, 129-31°; 4-AcNH, CH2CH2, 206° (decomposition); 4-CN, CH2CH2 (III), 143-8° (decomposition); 4-CONH2, CH2CH2, 197-9° (decomposition); 4-CO2Et, CH2CH2, 127-30° (decomposition). 4-CO2H, CH2CH2, 172-4° (decomposition); 4-CF3, CH2CH2, 158-9°; H, CH:CH, 128-30°; 4-NO2, CH:CH, 190-90.5°. The following IV were also prepared (X, A, and m.p. given): 4-NO2, CH2CH2, 118-21°; 2-NO2, CH2CH2, 125-7°; 4-CN, CH2CH2, 105-8°; 4-AcNH, CH2CH2, 159-60°; 4-CONH2, CH2CH2, 197-9°; 4-CO2Et, CH2CH2, 103-10°; 4-CO2H, CH2CH2, 232-5° (decomposition); 4-CF3, CH2CH2, 110-13°; 4-NO2, CH:CH, 188-90°. II and III were found to have hypoglycemic activity equal to chlorpropamide when tested by the modified method of Hoffman (CA 31, 85834). In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6SDS of cas: 2968-93-6).
2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 2968-93-6
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts