Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.HPLC of Formula: 40571-86-6
Practical resolution of racemic trans-2-benzylaminocyclohexanol with di-p-toluoyl-L-tartaric acid via diastereomeric salt formation based on the Pope and Peachey method was written by Ogawa, Ryuji;Fujino, Toshihiro;Hirayama, Noriaki;Sakai, Kenichi. And the article was included in Tetrahedron: Asymmetry in 2008.HPLC of Formula: 40571-86-6 This article mentions the following:
A new resolution process for racemic trans-2-(benzylamino)cyclohexanol, a key intermediate for chiral pharmaceuticals, was investigated. Di-p-toluoyl-L-tartaric acid was found to be a new practical resolving agent in terms of stability and productivity of the resolution system. Resolution conditions were optimized based on the Pope and Peachey method, and the best result was obtained when HCl was added to the resolution system as a supplemental acid; amino alc./tartaric acid/HCl = 1.0/0.6/0.4 (mol/mol/mol) (92% yield, 99.5% de, 92% resolution efficiency). In the experiment, the researchers used many compounds, for example, Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6HPLC of Formula: 40571-86-6).
Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.HPLC of Formula: 40571-86-6
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts