Ruthenium olefin metathesis catalysts with modified styrene ethers: influence of steric and electronic effects was written by Zaja, Mirko;Connon, Stephen J.;Dunne, Aideen M.;Rivard, Michael;Buschmann, Nicole;Jiricek, Jan;Blechert, Siegfried. And the article was included in Tetrahedron in 2003.Product Details of 15777-70-5 This article mentions the following:
A series of olefin metathesis catalysts with modified isopropoxybenzylidene ligands were synthesized, and the effects of ligands on the rate of metathesis was investigated. Increased steric hindrance ortho to the isopropoxy group enhanced reaction rates. In the case of N-heterocyclic carbene complexes, decreasing electron d. at both the chelating oxygen atom and the Ru:C bond accelerated reaction rates appreciably. In an example reaction, CH2:CHCH2N(Ts)CH2CH:CH2 underwent ring-closing metathesis in the presence of (4,5-dihydroIMes)Cl2Ru:CH(2-OiPr)(4-CN)C6H3 giving N-tosyl-2,5-dihydropyrrole in 96% yield. Catalysts containing a tricyclohexylphosphine ligand, such as (PCy3)Cl2Ru:CH(2-OiPr)(5-CF3)C3H6, followed the same trend with regard to benzylidene electrophilicity, while higher electron d. at oxygen enhanced reaction rates. In the experiment, the researchers used many compounds, for example, 4-Hydroxy-3-methylbenzonitrile (cas: 15777-70-5Product Details of 15777-70-5).
4-Hydroxy-3-methylbenzonitrile (cas: 15777-70-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Product Details of 15777-70-5
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts