Asymmetic hydrogenation of acetophenone and its derivatives catalyzed by L-proline modified Ir/γ-Al2O3 was written by Yang, Chao-fen;Yang, Jun;Zhu, Yan-qin;Sun, Xiao-dong;Chen, Hua. And the article was included in Fenzi Cuihua in 2013.COA of Formula: C8H9FO This article mentions the following:
Under the mild conditions, supported iridium catalyst stabilized and modified by L-proline was prepared The asym. hydrogenation of acetophenone and its derivatives catalyzed by the catalyst was studied. The effects of the concentration of L-proline, different solvents, different base additives and concentration of base, and hydrogen pressure were evaluated in detail. The results show that this catalytic system had higher activity and enantioselectivity than the supported metal catalysts which were modified by the nature chiral modifier in the reaction of asym. hydrogenation of acetophenone and its derivatives The conversion and the enantioselectivity for the asym. hydrogenation of acetophenone were 92.1% and 32.9%, resp. Especially, the enantioselectivity for asym. hydrogenation of 2′-fluoroacetophenone was 39.3%. The catalyst can be reused five times with a little loss of the enantioselectivity. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4COA of Formula: C8H9FO).
(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.COA of Formula: C8H9FO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts