Preparation of 3-azetidinols with non-bulky 1-alkyl substituents was written by Higgins, Robert H.;Eaton, Quentin L.;Worth, Leroy Jr.;Peterson, Myra V.. And the article was included in Journal of Heterocyclic Chemistry in 1987.SDS of cas: 111043-48-2 This article mentions the following:
Condensation of (ClCH2)2CHOR (R = tetrahydropyranyl, Me3Si) with R1NH2 (R1 = Me, Et, Me2CH, Me3C, 3-MeOC6H4CH2, 4-R2C6H4CH2, R2 = H, F, Me, MeO), followed by acid hydrolysis gave azetidinols I (R = H) in 0-26% yields. Silylation of R1NHCH(OH)CH2Cl with AcNHSiMe3, followed by cyclization gave siloxyazetidines I (R = Me3Si) in 16-59% yields. Desilylation of I (R = Me3Si) with dilute HCl or catalytic NaOMe in MeOH gave I (R = H) in 57-95% yields. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-1-methylazetidine (cas: 111043-48-2SDS of cas: 111043-48-2).
3-Hydroxy-1-methylazetidine (cas: 111043-48-2) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.SDS of cas: 111043-48-2
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts