Empirical Analysis Revealing Privileged Chemical Space of Cosmetic Preservatives was written by Storz, Michael P.;Holsten, Lea. And the article was included in Cosmetics in 2021.Electric Literature of C7H6Cl2O This article mentions the following:
Most cosmetic products require preservation to prevent microbial contamination and to ensure consumer safety. Due to regulatory restrictions and rejection by consumers, preservative options have become limited and the development of novel solutions is needed. This search can be guided by knowledge about favorable chem. space for cosmetic preservatives. Therefore, we used preservatives allowed in the EU as training set and calculated various mol. properties. Empirical anal. revealed two separated areas of privileged chem. space with the net charge as distinctive property. The first area comprises the group of neutral and anionic preservatives and is characterized by low mol. size as well as limited hydrogen-bonding capacity, polarity, and flexibility. The second area includes cationic preservatives, which are rather diffusely distributed regarding mol. weight and hydrogen-bonding, however, all members share high flexibility. Both groups significantly differ from antibiotics, reflecting the specific requirement of cosmetic preservation. The mol. properties defining the privileged chem. space are easy to calculate, and thus, can provide guidance for the development of novel preservatives. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Electric Literature of C7H6Cl2O).
(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Electric Literature of C7H6Cl2O
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts