Discovery of novel hydantoins as selective non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE) was written by Sheppeck, James E.;Gilmore, John L.;Yang, Anle;Chen, Xiao-Tao;Xue, Chu-Biao;Roderick, John;Liu, Rui-Qin;Covington, Maryanne B.;Decicco, Carl P.;Duan, James J.-W.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Related Products of 121282-70-0 This article mentions the following:
A series of hydantoins, e.g., I, was designed and synthesized as structural alternatives to hydroxamate inhibitors of TACE. 5-Mono- and di-substituted hydantoins exhibited activity with IC50 values of 11-60 nM against porcine TACE in vitro and excellent selectivity against other MMPs. In the experiment, the researchers used many compounds, for example, tert-Butyl (trans-2-hydroxycyclohexyl)carbamate (cas: 121282-70-0Related Products of 121282-70-0).
tert-Butyl (trans-2-hydroxycyclohexyl)carbamate (cas: 121282-70-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Related Products of 121282-70-0
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts