Comparative metabolism of Sumithion-m-methyl-14C in several species of mammals in vivo was written by Miyamoto, Junshi;Mihara, Kazumasa;Hosokawa, Shunji. And the article was included in Nippon Noyaku Gakkaishi in 1976.SDS of cas: 60463-12-9 This article mentions the following:
When orally administered to dogs, mice, rats, and rabbits, Sumithion (I) [122-14-5] labeled with 14C at the m-Me position of the 4-nitro-m-tolyl moiety was readily absorbed and distributed into various organs. The 14C was rapidly and completely excreted, mainly in urine. Seventeen metabolites accounting for 92-99% of the total urinary 14C were identified. Free and conjugated 4-nitro-m-cresol (II) [2581-34-2] and the demethyl derivatives of I and sumioxon(III) were the major metabolites. Total II and the demethyl derivatives accounted for 63.5 and 7.9%, resp., of the total 14C in urine of male rabbits, whereas they accounted for 36.1 and 56.9%, resp., of the total 14C in urine of male dogs. II sulfate [60463-13-0] was found at higher levels than II and II glucuronide [55373-21-2]. The urine of rats and rabbits contained the demethyl derivative of aminosumithion (O,O-dimethyl O-4-amino-m-tolyl phosphorothioate (IV) [13306-69-9], 5-hydroxy-2-nitrobenzoic acid [610-37-7], 4-amino-m-tolyl sulfate [60463-07-2], 4-formylamino-m-cresol (V) [60463-08-3], V glucuronide [60463-14-1], and 3-hydroxymethyl-4-acetylaminophenol (VI) [60463-09-4]. III and IV were found in urine of rabbits, O,O-dimethyl O-4-acetylamino-3-hydroxymethylphenyl phosphorothioate [60463-10-7], O,O-dimethyl O-3-carboxy-4-nitrosophenyl phosphorothioate [60463-11-8], and 4-acetylamino-m-cresol [39495-15-3] in urine of rats, and 5-hydroxy-2-nitrobenzyl alc. [60463-12-9], V glucuronide, and VI in urine of dogs. No I was detected in urine of these mammals, though traces of I were found in feces of rats. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9SDS of cas: 60463-12-9).
3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.SDS of cas: 60463-12-9
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts