Hyaluronic Acid Conjugates of TLR7/8 Agonists for Targeted Delivery to Secondary Lymphoid Tissue was written by Yoo, Euna;Salyer, Alex C. D.;Brush, Michael J. H.;Li, Yupeng;Trautman, Kathryn L.;Shukla, Nikunj M.;De Beuckelaer, Ans;Lienenklaus, Stefan;Deswarte, Kim;Lambrecht, Bart N.;De Geest, Bruno G.;David, Sunil A.. And the article was included in Bioconjugate Chemistry in 2018.Synthetic Route of C8H7NO This article mentions the following:
Immunogens carried in lymphatic fluid drain via afferent vessels into regional lymph nodes and facilitate the efficient induction of appropriate immune responses. The lymphatic system possesses receptors recognizing hyaluronic acid (HA). Covalent conjugates of small-mol. TLR7/8 agonists with HA are entirely devoid of immunostimulatory activity in vitro. In murine models of immunization, however, such conjugates traffic to lymph nodes, where they are ‘unmasked’, releasing the small mol. TLR7/8 agonist from the carrier polysaccharide. The resulting focal immunostimulation is manifested in potent adjuvant effects with negligible systemic exposure. The efficient delivery of immunogens has been a major challenge in the development of subunit vaccines, and enhancing targeted delivery of immunogens to secondary lymphoid organs might be a promising approach for improving vaccine efficacy, as well as safety. In the experiment, the researchers used many compounds, for example, 4-Hydroxy-3-methylbenzonitrile (cas: 15777-70-5Synthetic Route of C8H7NO).
4-Hydroxy-3-methylbenzonitrile (cas: 15777-70-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Synthetic Route of C8H7NO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts