Deracemization of 1-phenylethanols in a one-pot process combining Mn-driven oxidation with enzymatic reduction utilizing a compartmentalization technique was written by Sato, Hirofumi;Yamada, Rei;Watanabe, Yomi;Kiryu, Takaaki;Kawano, Shintaro;Shizuma, Motohiro;Kawasaki, Hideya. And the article was included in RSC Advances in 2022.Recommanded Product: (R)-1-(3-Chlorophenyl)ethanol This article mentions the following:
Racemic 1-phenylethanols were converted into enantiopure (R)-1-phenylethanols via a chemoenzymic process in which manganese oxide driven oxidation were coupled with enzymic biotransformation by compartmentalization of the reactions, although the two reactions conducted under mixed conditions were not compatible due to enzyme deactivation by Mn ions. Achiral 1-phenylethanol was oxidized to produce acetophenone in the interior chamber of a polydimethylsiloxane thimble. The acetophenone passes through the membrane into the exterior chamber where enantioselective biotransformation takes place to produce (R)-1-phenylethanol with an enantioselectivity of >99% ee and with 96% yield. The developed sequential reaction could be applied to the deracemization of a wide range of methyl- and chloro-substituted 1-phenylethanols (up to 93%, >99% ee). In addition, this method was applied to the selective hydroxylation of ethylbenzene to afford chiral 1-phenylethanol. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Recommanded Product: (R)-1-(3-Chlorophenyl)ethanol).
(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: (R)-1-(3-Chlorophenyl)ethanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts