Hard gelatine capsules: DEM supported experimental study of particle arrangement effect on properties and vibrational transport behavior was written by Jezerska, Lucie;Prokes, Rostislav;Gelnar, Daniel;Zegzulka, Jiri. And the article was included in Powder Technology in 2022.Safety of Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate This article mentions the following:
Hard gelatine capsules remain a relevant dosage form for today′s pharmaceutical manufacturing A wide range of color and print options supports marketing, brand image and patient loyalty. However, the filling of these capsules with various modern dosage forms and combinations thereof may affect their further processing. Therefore, a detailed study was carried out to assess the effect of mech.-phys. properties on the behavior of differently filled hard gelatine capsules. Capsules filled with powder, free or fixed particles presenting drug microforms and also hard gelatine capsules themselves were evaluated. Basic mech.-phys. characterization was performed on all samples. Furthermore, their transport on the vibrating conveyor was assessed and simulated using DEM. The results showed a significant influence mainly by the degree of capsule imbalance, i.e., the arrangement of particles in the capsule. It was found that the hard gelatine capsules showed an average of 15.6° lower values for the effective angle of internal friction compared to the powd. vitamin mixture, and in parallel, an average of 14.7° lower values for the static angle of repose were also recorded. The results of the experiments on the vibrating conveyor at a frequency setting of 15 Hz showed three times longer transport time for the vitamin mixture compared to the capsules. Increasing the frequency evened out these differences. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6Safety of Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate).
Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Safety of Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts