Activation of Remote meta-C-H Bonds in Arenes with Tethered Alcohols: A Salicylonitrile Template was written by Zhang, Lanlan;Zhao, Chaoyue;Liu, Yang;Xu, Jiancong;Xu, Xiufang;Jin, Zhong. And the article was included in Angewandte Chemie, International Edition in 2017.Application of 94022-96-5 This article mentions the following:
Palladium-catalyzed activation of remote meta-C-H bonds in arenes containing tethered alcs. was achieved with high regioselectivity by using a nitrile template. Computational studies on the macrocyclic transition state of the regioselectivity-determining C-H activation steps revealed that both the C-N-Ag angles and gauche conformations of Ph ether play an extremely important role in the meta selectivity. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Application of 94022-96-5).
2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application of 94022-96-5
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts