Integrative analysis of metabolomics and proteomics reveals amino acid metabolism disorder in sepsis was written by Chen, Qi;Liang, Xi;Wu, Tianzhou;Jiang, Jing;Jiang, Yongpo;Zhang, Sheng;Ruan, Yanyun;Zhang, Huaping;Zhang, Chao;Chen, Peng;Lv, Yuhang;Xin, Jiaojiao;Shi, Dongyan;Chen, Xin;Li, Jun;Xu, Yinghe. And the article was included in Journal of Translational Medicine in 2022.Formula: C16H16O3 This article mentions the following:
Sepsis is defined as a systemic inflammatory response to microbial infections with multiple organ dysfunction. This study analyzed untargeted metabolomics combined with proteomics of serum from patients with sepsis to reveal the underlying pathol. mechanisms involved in sepsis. A total of 63 patients with sepsis and 43 normal controls were enrolled from a prospective multicentre cohort. The biol. functions of the metabolome were assessed by coexpression network anal. A mol. network based on metabolomics and proteomics data was constructed to investigate the key mols. Untargeted metabolomics anal. revealed widespread dysregulation of amino acid metabolism, which regulates inflammation and immunity, in patients with sepsis. Seventy-three differentially expressed metabolites (|log2 fold change| > 1.5, adjusted P value < 0.05 and variable importance in the projection (VIP) > 1.5) that could predict sepsis were identified. External validation of the hub metabolites was consistent with the derivation results (area under the receiver operating characteristic curve (AUROC): 0.81-0.96/0.62-1.00). The pentose phosphate pathway was found to be related to sepsis-associated encephalopathy. Phenylalanine metabolism was associated with sepsis-associated acute kidney injury. The key mol. alterations of the multiomics network in sepsis compared to normal controls implicate acute inflammatory response, platelet degranulation, myeloid cell activation involved in immune response and phenylalanine, tyrosine and tryptophan biosynthesis, and arginine biosynthesis. Integrated anal. of untargeted metabolomics and proteomics revealed characteristic metabolite and protein alterations in sepsis, which were mainly involved in inflammation-related pathways and amino acid metabolism This study depicted the pathol. characteristics and pathways involved in sepsis and potential therapeutic targets. In the experiment, the researchers used many compounds, for example, 2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6Formula: C16H16O3).
2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Formula: C16H16O3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts