Identification of a series of PPARγ/δ dual agonists via solid-Phase parallel synthesis was written by Liu, Kevin G.;Lambert, Millard H.;Leesnitzer, Lisa M.;Oliver, William;Ott, Ronda J.;Plunket, Kelli D.;Stuart, Ludwig W.;Brown, Peter J.;Willson, Timothy M.;Sternbach, Daniel D.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2001.Name: 6-Methyl-2-pyridinemethanol This article mentions the following:
The authors have developed a general solid-phase synthesis for identification of PPAR (peroxisome proliferator-activated receptors) ligands. Synthesis of a 480-member library led to the identification of a potent PPARγ/δ dual agonist 23. Compound I showed good plasma exposure in rats and demonstrated antihyperglycemic and antihyperlipidemic efficacy in diabetic fatty Zucker rats. Compounds with PPARγ/δ dual activity may be useful in the treatment of metabolic syndrome X. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Name: 6-Methyl-2-pyridinemethanol).
6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Name: 6-Methyl-2-pyridinemethanol
Referemce:
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