Transition metal-free approach for late-stage benzylic C(sp3)-H etherifications and esterifications was written by Zhang, Yu;Sahoo, Prakash Kumar;Ren, Peng;Qin, Yuman;Cauwenbergh, Robin;Nimmegeers, Philippe;SivaRaman, Gandhi;Van Passel, Steven;Guidetti, Andrea;Das, Shoubhik. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Recommanded Product: 2216-51-5 This article mentions the following:
A transition metal-free approach for the regioselective functionalization of benzylic C(sp3)-H bonds using alcs. ROH (R = Me, t-Bu, cyclopentyl, etc.) and carboxylic acids R1C(O)OH (R1 = Ph, Me, cyclohexyl, etc.) as the nucleophiles was reported. This straightforward and general route has provided various benzylic ethers R2OR [R2 = 1-phenylethyl, 1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethyl, 5-acetylamino(2,3-dihydro-1H-inden-1-yl), etc.] and esters R2C(O)OR1, including twelve pharmaceutically relevant compounds In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Recommanded Product: 2216-51-5).
(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Recommanded Product: 2216-51-5
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts