Ni-Catalyzed Formal Cross-Electrophile Coupling of Alcohols with Aryl Halides was written by Lin, Quan;Ma, Guobin;Gong, Hegui. And the article was included in ACS Catalysis in 2021.Name: (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol This article mentions the following:
A strategy building upon in-situ halogenation/reductive coupling of alcs. with aryl halides to forge Csp2-Csp3 bonds was demonstrated. The combination of 2-chloro-3-ethylbenzo[d]oxazol-3-ium salt (CEBO) and TBAB as the mild bromination reagents enabled rapid transformation of a wide range of alcs. to their bromide counterparts within one to 5 min in CH3CN and DMF, which was compatible with the Ni-catalyzed cross-electrophile coupling conditions in the presence of a chem. reductant. The method is suitable for arylation of a myriad of structurally complex alcs. with no need for prepreparation of alkyl halides. More importantly, the mild and kinetically rapid bromination process showed good selectivity in the bromination/arylation of sym. diols and less sterically hindered hydroxyl groups in polyols, thus offering promise for selective functionalization of diols and polyols without laborious protecting/deprotecting operations. The practicality of this work was also evident in the arylation of a number of carbohydrates, drug compounds, and naturally occurring alcs. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Name: (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol).
(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Name: (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts