Transition-metal-catalyst-free synthesis of anthranilic acid derivatives by transfer hydrogenative coupling of 2-nitroaryl methanols with alcohols/amines was written by Zhang, Shudi;Tan, Zhenda;Xiong, Biao;Jiang, Huan Feng;Zhang, Min. And the article was included in Organic & Biomolecular Chemistry in 2018.Formula: C8H9NO3 This article mentions the following:
A series of anthranilic acid derivatives I [R1 = H, 6-Me, 4,5-(OMe)2, etc.; R2 = NH2, i-OPr, NH(CH2)2Ph, etc.] was synthesized by transfer hydrogenative coupling of 2-nitroaryl methanols with alcs./amines. The synthesis proceeded with the merits of no need for a transition metal catalyst, operational simplicity, broad substrate scope, good functional tolerance and high step efficiency, which offers a useful alternative to access anthranilic acid derivatives I and II. In the experiment, the researchers used many compounds, for example, (3-Methyl-2-nitrophenyl)methanol (cas: 80866-76-8Formula: C8H9NO3).
(3-Methyl-2-nitrophenyl)methanol (cas: 80866-76-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Formula: C8H9NO3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts