Transition Metal-Free Synthesis of meta-Bromo- and meta-Trifluoromethylanilines from Cyclopentanones by a Cascade Reaction was written by Staudt, Markus;Cetin, Adnan;Bunch, Lennart. And the article was included in Chemistry – A European Journal in 2022.COA of Formula: C4H11NO This article mentions the following:
A transition metal-free method for the synthesis of meta-bromo- and meta-trifluoromethylanilines starting from 3-tribromomethylcyclopentanone or 3-(2-bromo-2-chloro-1,1,1-trifluoroethyl)cyclopentanone, resp. was reported. The scope of the transformation was shown by application of primary, secondary and aromatic amines. The reaction proceeded in acceptable to high yields (20-81%), and allows for the synthesis of anilines with substitution patterns otherwise difficult to access. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3COA of Formula: C4H11NO).
(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.COA of Formula: C4H11NO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts