Synthesis of rigid and C2-symmetric pyridino-15-crown-5 type macrocycles bearing diamide-diester functions: enantiomeric recognition for chiral primary organoammonium perchlorate salts was written by Seker, Sevil;Baris, Deniz;Arslan, Nevin;Turgut, Yilmaz;Pirinccioglu, Necmettin;Togrul, Mahmut. And the article was included in Tetrahedron: Asymmetry in 2014.Application of 5856-63-3 This article mentions the following:
Four novel C2-sym. macrocyclic compounds with a pyridine function and possessing amide and ester linkages were prepared The enantiomeric discrimination abilities of these macrocycles against α-phenylethylammonium and α-(1-naphthyl)ethylammonium perchlorate salts were measured by standard 1H NMR titration techniques in DMSO-d6. A binding constant ratio of 31 (Kbind(S)/Kbind(R)) for two enantiomers of α-(1-naphthyl)ethylammonium salt with the macrocyclic host (S,S)-4 bearing Ph arms was observed, which corresponds to an enantiomeric discrimination of ∼94%. Mol. dynamic calculations were performed for some of the supramol. complexes to gain insight into the mode of mol. recognition between the macrocyclic compounds and ammonium salts; these results were consistent with exptl. observations, which may be relevant to those in biochem. processes occurring in organisms. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Application of 5856-63-3).
(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application of 5856-63-3
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts