The first application of C2-symmetric ferrocenyl phosphinite ligands for rhodium-catalyzed asymmetric transfer hydrogenation of various ketones was written by Ak, Bunyamin;Aydemir, Murat;Durap, Feyyaz;Meric, Nermin;Baysal, Akin. And the article was included in Inorganica Chimica Acta in 2015.Name: (R)-2-Aminobutan-1-ol This article mentions the following:
Homogeneous catalysis has been responsible for many major recent developments in synthetic organic chem. The combined use of organometallic and coordination chem. has produced a number of new and powerful synthetic methods for important classes of compounds in general and for optically active substances in particular. For this aim, a new class of chiral modular C2-sym. ferrocenyl phosphinite ligands has been prepared in good yields by using the inexpensive 1,1′-ferrocenedicarboxyaldehyde and various ferrocene based-amino alcs. as starting materials, and applied in the rhodium(I)-catalyzed asym. transfer hydrogenation (ATH) of aromatic ketones to give corresponding secondary alcs. with excellent enantioselectivities and reactivities using isoPrOH as the hydrogen source (up to 99% conversion and 99% ee). The substituents on the backbone of the ligands are found to exhibit a remarkable effect on both the activity and % ee. The structures of these ligands and their complexes have been elucidated by a combination of multinuclear NMR spectroscopy, IR spectroscopy and elemental anal. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Name: (R)-2-Aminobutan-1-ol).
(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Name: (R)-2-Aminobutan-1-ol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts