Ospemifene for the treatment of postmenopausal vulvar and vaginal atrophy: recommendations for clinical use was written by Pinkerton, JoAnn V.;Kagan, Risa. And the article was included in Expert Opinion on Pharmacotherapy in 2015.Quality Control of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol This article mentions the following:
Vulvular vaginal atrophy (VVA), a component of genitourinary syndrome of menopause, is a chronic, progressive medical condition that results from estrogen deficiency at menopause. Ospemifene is a nonhormonal, estrogen receptor agonist/antagonist (ERAA) FDA-approved fro the treatment of moderate to severe dyspareunia, a symptom of VVA, due to menopause. PubMed was searched from inception to March 2015 with keywords ospemifene and vulvar vaginal atrophy; no other similar clin. reviews were found. This is a comprehensive review describing the clin. safety and efficacy of ospemifene for the treatment of dyspereunia and VVA. Ospemifene is an approved oral option for postmenopausal women seeking treatment for VVA with bothersome dyspareunia, particularly for those who have tried and failed over-the-counter options or do not want vaginal therapies. Further clin. studies are needed to evaluate the preclin. and early clin. findings of antagonistic to neutral effect on breast tissue and pos. effect on bone, which, in the future, may support the use of ospemifene to prevent bone loss or treat VVA in women at high risk or with breast cancer. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Quality Control of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol).
(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Quality Control of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts