Well-Defined NNS-Mn Complex Catalyzed Selective Synthesis of C-3 Alkylated Indoles and Bisindolylmethanes Using Alcohols was written by Mondal, Avijit;Sharma, Rahul;Dutta, Bishal;Pal, Debjyoti;Srimani, Dipankar. And the article was included in Journal of Organic Chemistry in 2022.Computed Properties of C7H7ClO This article mentions the following:
Herein, Mn-catalyzed selective C-3 functionalization of indoles with alcs was demonstrated. The developed catalyst can also furnish bis(indolyl)methanes from the same set of substrates under slightly modified reaction conditions. Mechanistic studies revealed that the C-3 functionalization of indoles was going via a borrowing hydrogen pathway. To highlight the practical utility, a diverse range of substrates including nine structurally important drug mols. were synthesized. Furthermore, a one-pot cascade strategy for synthesizing C-3 functionalized indoles directly from 2-aminophenyl ethanol and alc. was also introduced. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Computed Properties of C7H7ClO).
(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Computed Properties of C7H7ClO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts