Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2854-16-2, name is 1-Amino-2-methylpropan-2-ol. A new synthetic method of this compound is introduced below., 2854-16-2
(a)N-(2-hydroxy-2-methyl-propyl)-3-methoxy-4-nitro-benzamideA mixture of 3-methoxy-4-nitrobenzoic acid (1 g, 5.07 mmcl), HATU (2.31 g, 6.1mmcl), and 1-amino-2-methyl-propan-2-ol (1.13 g, 12.7 mmol) in dichloromethane (20 mL) was stirred on an ice-cold water bath, and DiPEA (2.2 mL, 12.7 mmol) was added. After 10 mm the mixture was allowed to warm to room temperature and stirred for I h. The mixture was diluted with ethyl acetate (100 mL) and subsequently washed with 5percent sodium bicarbonate solution (3x 75 mL) water and brine, dried over sodium sulfate and concentrated in vacuo to yield 1.47 gof crude N-(2-hydroxy-2-methyl-propyl)-3-methoxy-4-nitro-benzamide (quant.).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,2854-16-2, 1-Amino-2-methylpropan-2-ol, and friends who are interested can also refer to it.
Reference:
Patent; NETHERLANDS TRANSLATIONAL RESEARCH CENTER B.V.; DE MAN, Adrianus Petrus Antonius; BUIJSMAN, Rogier Christian; STERRENBURG, Jan Gerard; UITDEHAAG, Joost Cornelis Marinus; DE WIT, Joeri Johannes Petrus; ZAMAN, Guido Jenny Rudolf; WO2015/155042; (2015); A1;,
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