The long-arm effect: influence of axially chiral phosphoramidite ligands on the diastereo- and enantioselectivity of the tandem 1,4-addition/fluorination was written by Wang, Lian;Meng, Wei;Zhu, Chuan-Le;Zheng, Yan;Nie, Jing;Ma, Jun-An. And the article was included in Angewandte Chemie, International Edition in 2011.HPLC of Formula: 863659-89-6 This article mentions the following:
Alkylidene-substituted β-aryl β-ketoesters undergo asym. tandem Michael addition and electrophilic fluorination in reaction with dialkylzinc compounds and N-fluorobenzenesulfonimide, catalyzed by copper(II) triflate, modified with axial chiral 1,1′-binaphthalene 2,2′-phosphoramidite monodentate ligands QO2PNR32 (1a–r, Q = 3,3′-diaryl-1,1′-binaphthalene-2,2-diyl, R3 = Me, Et, iPr, Bu), yielding α-fluoro-β-ketoesters I (3a–v, R = H, 4-MeO, 3-Me, 2-Me, 4-Cl, 4-Br; R1 = Et, Me, n-Pr, Bu; R2 = Ph, 2-MeOC6H4, 3-MeOC6H4, 4-MeOC6H4, 4-CF3C6H4, 2-naphthyl, 2-furyl, 2-thienyl)with high yields and >85% ee. The variety of 3,3′-disubstituted chiral phosphoramidites were evaluated, the 4-biphenylyl and 4-(2-naphthyl)phenyl substituents provided optimal chiral induction, 75-90%. N-Substituents of the phosphoramidites 1 play a minor role in induction, the diethylamino group as NR32 being optimal. In the experiment, the researchers used many compounds, for example, (S)-[2,3′:1′,1”:3”,2”’-Quaternaphthalene]-2′,2”-diol (cas: 863659-89-6HPLC of Formula: 863659-89-6).
(S)-[2,3′:1′,1”:3”,2”’-Quaternaphthalene]-2′,2”-diol (cas: 863659-89-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.HPLC of Formula: 863659-89-6
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts