Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor was written by Arasappan, Ashok;Bennett, Frank;Bogen, Stephane L.;Venkatraman, Srikanth;Blackman, Melissa;Chen, Kevin X.;Hendrata, Siska;Huang, Yuhua;Huelgas, Regina M.;Nair, Latha;Padilla, Angela I.;Pan, Weidong;Pike, Russell;Pinto, Patrick;Ruan, Sumei;Sannigrahi, Mousumi;Velazquez, Francisco;Vibulbhan, Bancha;Wu, Wanli;Yang, Weiying;Saksena, Anil K.;Girijavallabhan, Viyyoor;Shih, Neng-Yang;Kong, Jianshe;Meng, Tao;Jin, Yan;Wong, Jesse;McNamara, Paul;Prongay, Andrew;Madison, Vincent;Piwinski, John J.;Cheng, Kuo-Chi;Morrison, Richard;Malcolm, Bruce;Tong, Xiao;Ralston, Robert;Njoroge, F. George. And the article was included in ACS Medicinal Chemistry Letters in 2010.HPLC of Formula: 29364-29-2 This article mentions the following:
Boceprevir (SCH 503034), 1, a novel HCV NS3 serine protease inhibitor discovered in our laboratories, is currently undergoing phase III clin. trials. Detailed investigations toward a second generation protease inhibitor culminated in the discovery of narlaprevir (SCH 900518), 37, with improved potency (∼10-fold over 1), pharmacokinetic profile and physicochem. characteristics, currently in phase II human trials. Exploration of synthetic sequence for preparation of 37 resulted in a route that required no silica gel purification for the entire synthesis. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2HPLC of Formula: 29364-29-2).
Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.HPLC of Formula: 29364-29-2
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts