Optimizing the morphology of calcium
Calcium D-pantothenate, also known as VB5, is one of the most important feed additives. It typically assumes a needle-like morphol. that easily agglomerates, resulting in poor flowability and low bulk d. Here, we develop a route to prepare calcium D-pantothenate in a block-like morphol. with good flowability and high bulk d. Also, the solvent-mediated phase transformation of calcium D-pantothenate methanol solvate (D-PC·MeOH) into D-pantothenate tetramethanol monohydrate (D-PC·4MeOH·H2O) was investigated by in situ ATR-FTIR spectrometry and Raman spectrometry, and the data was subsequently correlated by the Johnson-Mehl-Avrami model. Results demonstrate that the rate-controlling step was the nucleation and growth of D-PC·4MeOH·H2O. Careful control over the thermal transformation process of D-PC·4MeOH·H2O enabled the formation of solvent-free calcium D-pantothenate in a block-like morphol. Mol. dynamics simulations enabled a deeper understanding of the effects of temperature on the phase transformation process. This work provides a framework to scale the production of calcium D-pantothenate to industrial levels. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6Application of 137-08-6).
Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Application of 137-08-6
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts