Chemical profiling, antioxidant, enzyme inhibitory and in silico modeling of Rosmarinus officinalis L. and Artemisia herba alba Asso. essential oils from Algeria was written by Amina, Benabdallah;Soumeya, Betina;Salim, Bouchentouf;Mahieddine, Boumendjel;Sakina, Bechkri;Chawki, Bensouici;Francesca, Nicoli;Marzia, Vergine;Carmine, Negro;Luigi, De Bellis. And the article was included in South African Journal of Botany in 2022.Application In Synthesis of 5-Isopropyl-2-methylphenol This article mentions the following:
In the current study, the chem. composition, antioxidant, α-glucosidase, α-amylase and cholinesterase inhibitory activities of wormwood and rosemary essential oils were investigated. In order to explain the interaction of chem. constituents with the enzymes, mol. docking tools were used. GC/MS analyses revealed that the main compounds of rosemary oil were eucalyptol (37.97%), followed by camphor (11.84%). Whereas β-copaene (16.22%), limonene (14.56%), eucalyptol (14.49%) and camphor (13.74%) represent the main compounds of wormwood oil. Moreover, antioxidant abilities assessed by DPPH radical scavenging, β-carotene bleaching inhibitory and ion chelating test showed that rosemary oil was more efficient than wormwood. Furthermore, rosemary oil exhibited even better results against cholinesterase inhibitory. However, wormwood oil was more effective for antidiabetic inhibitory enzymes. The theor. verification by mol. modeling revealed that linalool, terpinen-4-ol, eugenol Me ether and Τ-cadinol have the best binding affinity with studied enzymes. In conclusion, docking verification has shown a good affinity of some chem. compounds from rosemary more than wormwood with studied enzymes explaining the assessed biol. activities. Rosemary and wormwood exhibited interesting biol. activities that explain the traditional uses of these plants that could be further explored for food and pharmaceutical industries. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Application In Synthesis of 5-Isopropyl-2-methylphenol).
5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Application In Synthesis of 5-Isopropyl-2-methylphenol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts