Glyphaeaside C-enriched extract of Glyphaea brevis restored the antioxidant and reproductive integrity of 1,4-Dinitrobenzene-intoxicated rats was written by Olugbodi, Janet Olayemi;Olaleye, Mary Tolulope;Mostafa-Hedeab, Gomaa;Alqarni, Mohammed;Ilesanmi, Omotayo Babatunde;Batiha, Gaber El-Saber;Akinmoladun, Afolabi Clement. And the article was included in Biomedicine & Pharmacotherapy in 2022.Computed Properties of C4H10O4 This article mentions the following:
This study assessed the fertility potential of methanol leaf extract of Glyphaea brevis (MGB) in rats exposed to 1,4-Dinitrobenzene (DNB), an environmental reprotoxicant. Male Wistar rats were orally exposed to 50 mg/kg DNB and administered 750 mg/kg MGB, 1500 mg/kg MGB or 300 mg/kg vitamin E for 21 days after 48 h of DNB exposure. Determination of serum reproductive hormone levels by enzyme-linked immunosorbent assays, evaluation of hematol. profile, computer-assisted sperm analyses (CASA) of sperm kinematics and morphol., assessment of testicular and spermatozoan antioxidant systems, and histopathol. evaluation of reproductive tissues were performed. HPLC-DAD anal. identify Glyphaeaside C as the major component of the extract In rats toxified with 50 mg/kg DNB, testicular and epididymal weights, serum levels of LH, testosterone and FSH, and packed cell volume, Hb concentration, and white blood cell counts were decreased. There was altered sperm kinematics which reflected in increased sperm abnormalities. Treatment with the Glyphaeaside C -enriched MGB counteracted all DNB-induced changes and corrected DNB-induced aberrations in kinematic endpoints. Also, testicular and epididymal antioxidant systems were disrupted and there was damage to tissue histoarchitecture. Furthermore, our mol. docking study revealed that Glyphaeaside-C exhibited high binding affinities to the binding pocket of some free radical generating enzymes. Conclusively, the results indicated that Glyphaeaside C-enriched extract of Glyphaea brevis leaf enhanced the quality of semen and improved the functional capabilities of spermatozoa following exposure of rats to DNB which could translate to enhanced fertility. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Computed Properties of C4H10O4).
(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Computed Properties of C4H10O4
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts