927-74-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 927-74-2, name is 3-Butyn-1-ol. This compound has unique chemical properties. The synthetic route is as follows.
To a stirred solution of but-3-ynol (3.0 mL, 40 mmol) in dry CH2Cl2 (20 mL) was added N-methylimidazole (9.52 mL, 120 mmol), iodine (0.8 g, 120 mmol) and tert-butyldimethylsilyl chloride (6.63 g, 44 mmol). After 4-5 h at room temperature, the solution was washed with saturated aq. Na2S2O3, brine, and water, dried over MgSO4 and evaporated under reduced pressure. Purification of the residue by column chromatography (hexane:EtOAc, 9:1, Rf 0.9) gave protected butynol 7 (7.1 g, 90%) as an oil. deltaH (400 MHz; CDCl3) 0.06 (6H, s, Me2Si), 0.89 (9H, s, tBu), 1.94 (1H, t, J 2.4, CH?C), 2.39 (2H, dt, J 2.4 and 7.2, OCH2CH2), 3.73 (2H, t, J 7.2, OCH2); deltaC (100 MHz, CDCl3) -5.31 Me2Si), 18.3 (CMe3), 22.8 (OCH2CH2), 25.8 (CMe3), 61.7 (OCH2), 69.2 (CH?C), 81.5 (CH?C); IR, numax/cm-1 2857 (C-H), 2122 (C?C), 1472 (C-H), 1103 (C-O).
Statistics shows that 927-74-2 is playing an increasingly important role. we look forward to future research findings about 3-Butyn-1-ol.
Reference:
Article; Iqbal, Amjid; Sahraoui, El-Habib; Leeper, Finian J.; Beilstein Journal of Organic Chemistry; vol. 10; (2014); p. 2580 – 2585;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts