Hybrid responsive hydrogel carriers for oral delivery of low molecular weight therapeutic agents was written by Caldorera-Moore, M.;Maass, K.;Hegab, R.;Fletcher, G.;Peppas, N.. And the article was included in Journal of Drug Delivery Science and Technology in 2015.Related Products of 109-17-1 This article mentions the following:
Hydrogels have been influential in the development of controlled release systems for a wide variety of therapeutic agents. These materials are attractive as carriers for transmucosal and intracellular drug delivery because of their inherent biocompatibility, tunable physicochem. properties, basic synthesis, and ability to be physiol. responsive. Due to their hydrophilic nature, hydrogel-based carrier systems are not always the best systems for delivery of small mol. weight, hydrophobic therapeutic agents. In this work, versatile hydrogel-based carriers composed of copolymers of Me methacrylate (MMA) and acrylic acid (AA) were designed and synthesized to create formulations for oral delivery of small mol. weight therapeutic agents. Through practical material selection and careful design of copolymer composition and mol. architecture, we engineered systems capable of responding to physiol. changes, with tunable physicochem. properties that are optimized to load, protect, and deliver their payloads to their intended site of action. The synthesized carriers’ ability to respond to changes in pH, to load and release small mol. weight drugs, and biocompatibility were investigated. Our results suggest these hydrophilic networks have great potential for controlled delivery of small-mol. weight, hydrophobic and hydrophilic agents. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Related Products of 109-17-1).
((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Related Products of 109-17-1
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts