Selective C-C bonds formation, N-alkylation and benzo[d]imidazoles synthesis by a recyclable zinc composite was written by Zhu, Guanxin;Duan, Zheng-Chao;Zhu, Haiyan;Ye, Dongdong;Wang, Dawei. And the article was included in Chinese Chemical Letters in 2022.Reference of 873-76-7 This article mentions the following:
Earth abundant metals are much less expensive, promising, valuable metals and could be served as catalysts for the borrowing hydrogen reaction, dehydrogenation and heterocycles synthesis, instead of noble metals. The uniformly dispersed zinc composites were designed, synthesized and carefully characterized by means of XPS, EDS, TEM and XRD. The resulting zinc composite showed good catalytic activity for the N-alkylation of amines 2-R-3-R1-4-R2-5-R3-C6HNH2 (R = H, Cl, Me; R1 = H, Cl; R2 = H, Cl, OMe; R3 = H, Me) with amines R4CH2NH2 (R4 = Ph, 2-methylphenyl, thiophen-2-yl, etc.), ketones R5C(O)CH3 (R5 = Ph, 3-bromophenyl, naphthalen-2-yl, etc.;) with alcs. R6CH2OH (R6 = Ph, 3,4-difluorophenyl, thiophen-2-yl, etc.) in water under base-free conditions, while unsaturated carbonyl compounds R5C(O)CH=CHR6 and R5C(O)(CH2)2R6 could also be synthesized by tuning the reaction conditions. Importantly, it was the first time to realize the synthesis of 2-aryl-1H-benzo[d]imidazole derivatives I (R7 = H, Cl, Me) by using this zinc composite under green conditions. Meanwhile, this zinc catalyst could be easily recovered and reused for at least five times. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Reference of 873-76-7).
(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Reference of 873-76-7
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts