Manganese complex-catalyzed oxidation and oxidative kinetic resolution of secondary alcohols by hydrogen peroxide was written by Miao, Chengxia;Li, Xiao-Xi;Lee, Yong-Min;Xia, Chungu;Wang, Yong;Nam, Wonwoo;Sun, Wei. And the article was included in Chemical Science in 2017.HPLC of Formula: 120121-01-9 This article mentions the following:
The highly efficient catalytic oxidation and oxidative kinetic resolution (OKR) of secondary alcs. has been achieved using a synthetic manganese catalyst with low loading and hydrogen peroxide as an environmentally benign oxidant in the presence of a small amount of sulfuric acid as an additive. The product yields were high (up to 93%) for alc. oxidation and the enantioselectivity was excellent (>90% ee) for the OKR of secondary alcs. Mechanistic studies revealed that alc. oxidation occurs via hydrogen atom (H-atom) abstraction from an α-CH bond of the alc. substrate and a two-electron process by an electrophilic Mn-oxo species. D. functional theory calculations revealed the difference in reaction energy barriers for H-atom abstraction from the α-CH bonds of R- and S-enantiomers by a chiral high-valent manganese-oxo complex, supporting the exptl. result from the OKR of secondary alcs. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9HPLC of Formula: 120121-01-9).
(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.HPLC of Formula: 120121-01-9
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts