Pharmaceutical excipients with potential to cause adverse effects in paediatric nasal medicines was written by Stjepanovic, Ana N.;Todorovic, Nemanja B.;Tesic, Tamara Z.;Komazec, Zoran S.;Canji-Panic, Jelena M.;Lalic-Popovic, Mladena N.. And the article was included in Regulatory Toxicology and Pharmacology in 2022.Synthetic Route of C3H8O2 This article mentions the following:
Some pharmaceutical excipients may cause adverse reactions, excipient-related interactions and/or contraindications. Due to the unique characteristics of the paediatric population, adverse effects may occur to substances generally thought safe. The proportion of topical nasal medicines approved for paediatric use and the prevalence and labeling of excipients with known effect (EKE) in these products were compared in Serbia as a non-EU country and Croatia and Slovenia as EU countries. The study was designed as a post-authorization safety study and safety of excipients was considered in accordance with recommendations of the European Medicines Agency (EMA). More than 90% of topical nasal medicines registered in the three countries were approved for paediatric use and more than half of these paediatric medicines contained EKE that may cause adverse effects. Benzalkonium chloride was found in 52.38%, 55.81% and 59.09% of these products in Serbia, Croatia and Slovenia, resp. Propylene glycol, benzyl alc., ethanol, Me paraben, Pr paraben and boric acid were also present in a few analyzed preparations A significant number of EKE labeling deficiencies were detected in all three countries, hindering healthcare professionals ′ access to information needed for adequate patient counselling. A revision of the nasal paediatric medicines ′ PLs and SmPCs is recommended. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Synthetic Route of C3H8O2).
1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Synthetic Route of C3H8O2
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts